@proceedings {5769, title = {BIOISOSTERIC SYNTHESIS AND U.V. SPECTRAL BEHAVIOUR OF TETRA-AZO FUSED RING PYRAZOLO-TETRAZINE AND PYRAZOLO-TRIAZINE MOIETIES HAVING VARIABLE HETERO ATOMS OXYGEN/SULFUR/NITROGEN POTENTIAL FOR PARTITION COEFFICIENT}, year = {2017}, month = {2-2-2017}, abstract = {

Solubility of any organic compounds in water or organic solvent depend on the presence of functional groups having electronegative atoms like oxygen, nitrogen and sulfur either in single entity or as a functional groups. The electronegativity of these atoms is as follows O: 3.44, N: 3.04, S: 2.58 which can act as heteroatoms in heterocyclic ring also either in fused ring or single ring. Solubility profile is determined by logarithmic partition coefficient values (logP) which is the ratio of solubility of compound in organic phase and water phase. The synthesized compounds are of two series: pyrazolo-tetrazine \& pyrazolo-triazine moieties having variable hetero atoms: Oxygen/Sulfur/Nitrogen which produce compounds. In pyrazolo-tetrazine ring system all four nitrogen atoms are in ring and three nitrogen atoms and subsequently placed serially whereas in pyrazolo-triazine three nitrogen atoms are in ring but in alternate positions separated by carbon atom so logP profile of pyrazolo-triazines are higher than pyrazolo-tetrazines [pyrazolo-triazines\>pyrazolo-tetrazines]

The three electronegative elements are O: 3.44, N: 3.04, S: 2.58 as hetero atoms are in active part to make fused ring heterocyclic moiety of five membered with six membered due to urea (X=O), thiourea (X=S) and guanidine (X=NH). Oxygen and sulfur both have two lone pair of electrons but electronegativity of O\>S and due to less electronegativity of sulfur the logP profile of sulfur derivative becomes higher than oxygen derivatives whereas in nitrogen there is one lone pair of electrons so the logP profile of nitrogen becomes more less.\ 

\ (A) \ (B) \ (C)

(D) (E) \ (F)

Both of series of 6-methyl-4-phenyl-8H-pyrazolo[1,2-a][1,2,3,5]tetrazine [A-C] and 7-methyl-4,6-diphenylpyrazolo[1,5-a][1,3,5]triazin [D-F] having same hetero atoms oxgen/sulfur/nitrogen shows different logP schedule due to the presence of one phenyl ring in tetrazine and two phenyl rings in triazine nucleus: pyrazolo-triazines\>pyrazolo-tetrazines and the partition coefficient of previous one is lesser than former series. logP of urea derivative of pyrazolo-tetrazine is less than urea derivative of the same ring, logP of thiourea derivative is higher than urea derivative of pyrazolo-tetrazine and logP of guanidine derivative is lesser than both urea and thiourea derivatives of pyrazolo-tetrazine.\  Pyrazolo-triazine series show higher values than pyrazolo-tetrazine series for all three cases of urea/thiourea/guanidine derivatives due to variable electronegativity.\ 

Keywords: pyrazolo-tetrazines, pyrazolo-triazines, logP

}, author = {Md. Abdullah Hil B. Rupak, Astha P. Sanyal, Yash B. Patel, Charmi P. Patel and Dhrubo Jyoti Sen and Saurabh Patel and Prof. Dr. Dhrubo Jyoti Sen and Kinsuk Sarker, Apurbo Sarker, Arittra Ghosh and Dhrubo Jyoti Sen} } @article {5772, title = {The Maillard Reaction of reducing sugars with amino acids in baking chemistry}, volume = {4}, year = {2017}, month = {1-1-2017}, pages = {6}, type = {Review}, edition = {2017}, author = {Prof. Dr. Dhrubo Jyoti Sen.} } @article {5770, title = {Bioisosteric synthesis and U.V. spectral behaviour of tetra-azo fused ring pyrazolo-tetrazine and pyrazolo-triazine moieties having variable hetero atoms oxygen/sulfur/nitrogen potential for partition coefficient}, journal = {World Journal of Pharmacy and Pharmaceutical Sciences}, volume = {5}, year = {2016}, month = {1-5-2016}, pages = {13}, type = {Research}, chapter = {1442-1454}, keywords = {DNA bioisosterism, electronegativity, keto-enol tautomerism, logP, molecular tailoring, pyrazolo-triazines, pyrazolotetrazines, urea/thiourea/guanidine, λmax.}, isbn = {2278{\textendash}4357}, issn = {2278{\textendash}4357}, author = {Md. Abdullah Hil B. Rupak and Prof. Dr. Dhrubo Jyoti Sen}, editor = {Astha P. Sanyal} } @book {5771, title = {Chemistry is a playground of functional groups}, series = {Chemistry is a playground of functional groups}, year = {2016}, pages = {373}, publisher = {Lambert Academic Publishing GmbH \& Co. KG}, organization = {Lambert Academic Publishing GmbH \& Co. KG}, address = {Germany}, isbn = {978-3-659-90892-7}, url = {https://www.lap-publishing.com/catalog/details/store/pt/book/978-3-659-90892-7/chemistry-is-a-playground-of-functional-groups?search=Polymer\%20extrusion}, author = {Dhrubo Jyoti Sen and Shruti Rai} } @article {5783, title = {POSOLOGICAL DOSE OF THERAPEUTICS OVER PROPHYLAXIS IN TOXICOLOGICAL SERENDIPITY}, volume = {2}, year = {2016}, month = {2016}, isbn = {2455-295X}, author = {Sarker, Kinsuk and Sarker, Apurbo and Ghosh, Arittra and Sen, Dhrubo Jyoti} } @article {5777, title = {Stress degradation studies on darunavir ethanolate using validated stability-indicating high-performance thin-layer chromatography}, journal = {World Journal of Pharmaceutical Research}, volume = {5}, year = {2016}, month = {1-12-2016}, pages = {19}, type = {Research}, chapter = {999-1018}, issn = {2277-7105}, author = {Palak G. Chaudhary and Prof. Dr. Dhrubo Jyoti Sen} } @article {5781, title = {Correlation approach between shotgun sequencing with DNA sequencing in molecular genomics}, volume = {3}, year = {2014}, month = {2014}, pages = {963 - 995}, author = {Parmar, Ashish M and Patel, Keyur D and Doshi, Nilang S and Kapadiya, Girish M and Patel, Bhavesh S and Sen, Dr Dhrubo Jyoti} } @article {5779, title = {DESIGN, SYNTHESIS AND ANTIVIRAL ACTIVITY OF 2-{[(2E)-3-(3, 4, 5-MONO/DI/TRI HYDROXYPHENYL) PROP-2-ENOYL] SULFANYL/AMINO} PROPANOIC ACIDS IN HUMAN PLASMA BY ROTOR GENE-Q (5 PLEX) REAL TIME PCR METHOD}, volume = {5}, year = {2014}, month = {2014}, pages = {4865}, isbn = {0975-8232}, author = {Chhipa, Nadim MR and Sen, Dhrubo Jyoti} } @article {5780, title = {Ear is the excellent acoustic reader: the effect of acoustics on this sophisticated organ}, volume = {2}, year = {2014}, month = {2014}, pages = {658 - 671}, isbn = {2321-547X}, author = {Sarker, Kinsuk Kalyan and Dadida, Clive and Dhliwayo, Paul and Sen, Dhrubo Jyoti} } @article {5782, title = {GUTKHA AS A CHARM IN IN-VITRO \& HARM IN IN-VIVO: A DEVIL IN DISGUISE}, year = {2014}, month = {2014}, author = {Sarker, Kinsuk Kalyan and Dadida, Clive and Dhliwayo, Paul and Sen, Dhrubo Jyoti} } @article {5778, title = {Investigation on newer anti-inflammatory, sedative-hypnotic and antimicrobial agents}, volume = {35}, year = {2000}, month = {2000}, issn = {0019-5464}, author = {Sen, Dhrubo Jyoti} }